Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. This project tested multiple samples from each tumor to see if there were variations within the same tumor, and found striking differences which may have a mahor effect on treatments. If true (and this was a small study which needs to be repeated), then the concept of personalized medicine - targetting the tumor's specific mutations - might not work, as they found different parts of the tumor had different subtypes.
Reversing the Warburg Effect as a Treatment for Glioblastoma. The "Warburg effect" is an observation that cancer cells usually metabolize glucose differently than normal cells. These researchers are trying to change the process back to how it is in normal cells using a relatively simple chemical. This is only in the test tube now and more research is needed before we can tell if it works in people.
