Disseminated progression of glioblastoma after treatment with bevacizumab. Avastin has gotten a lot of bad press recently. Here is some good news about Avastin from UCSF - one of the best brain tumor centers in the world!
There have been reports that Avastin causes the tumor to become more invasive. The thinking is that it works by stopping the tumor from forming new blood vessels, which are needed for the tumor to grow. However, when you cut off the blood supply to the tumor, you would think it makes sense that the tumor cells migrate and look for a new blood supply. There have been some reports that Avastin makes the tumor more invasive. This report says that is not true.
Mechanisms of evasive resistance to anti-VEGF therapy in glioblastoma. This sounds like one of the most promising avenues of research... find out why Avastin stops working and how to turn that around. I feel that the answer to this question may lead to a major breakthrough, hopefully using drugs that are already available so it can be used by all who need it quickly.
