Long-term treatment with temozolomide in malignant glioma. It never made sense to me to stop Temodar at 6 months. The reason they always give is that is the length of time used in the trial was 6 months so they use that. However, that 6 months was chosen to allow the trial to conclude quickly. They never tested varying lengths of treatment against each other. The other argument to end treatment early was increased chance of side effects. This article shows in a small group, that it is relatively safe to continue for an extended period of time. There is also the risk of developing a secondary cancer - but that risk is smaller than the original tumor growing back and killing you.
