Colchicine derivative as a potential anti-glioma compound. I thought about this a long time ago.. Colchicine is a drug that stops cells from dividing by stopping the cell cycle at a specific point. It would make sense that it would be useful for cancer but it is too toxic at high doses. I always thought it might be a good drug to try for brain tumors using it directly in the brain, not systemic so you don't get the systemic side effects. Perhaps combining it with something like the Optune system would work much better as more tumor cells would be in the middle of the cell cycle where Optune works the best.
Creating derivatives of it that aren't as toxic is worth trying.
