Association between human cytomegalovirus infection and histone acetylation level in various histological types of glioma. This is a controversial topic in the brain tumor world. Studies have shown that most or all gbm samples contain this virus. However, other studies show that few or none have it. That difference may be related to the ability of the lab to detect it. There needs to be a standardized way of detecting it so we can settle that once and for all. There has been a human study of an anti CMV drug (Valcyte) that has shown very good results, but the study was questioned by others saying it wasn't designed properly. My thoughts are we need more studies on anti-CMV therapies, but in the meantime it might be worth adding it to the planned treatment regimen. It would be best to track patients who try this in our brain tumor virtual trial so we can quickly tell if there is any effect - good or bad.
