PD-1 blockade enhances the vaccination induced
immune response in glioma This combination of vaccine and checkpoint inhibitor worked much better than either alone, at least in mice. Hopefully they can move this to patients quickly, as the checkpoint inhibitor is already FDA approved for other diseases and they are already running a trial of the vaccine.
By the way - they acknowledge the Musella Foundation For Brain Tumor Research & Information, Inc as a source of funding! This is your donations at work!
Local Biotech Company Develops Therapy to Treat Brain Cancer for Extended Survival Although it was only a small phase 1 trial, they reported that the overall survival doubled compared to historical controls. This is now in a large phase 2/3 trial throughout the USA. We are working on raising funds to help speed up the approval process so all brain tumor patients could get access. Eventually, this may work for not only brain but most other types of cancer.
