Market Research Opportunity for GBM Patients - ONLINE SURVEY This is another market research survey. The Musella Foundation gets a donation from them when patients take the survey. They recently donated $2,500 to us, as well as paying each participant $70. Not bad for 30 minutes of your time! Let me know if you take the survey!
Defining optimal cutoff value of MGMT promoter methylation by ROC analysis for clinical setting in glioblastoma patients. Until recently, this did not matter much, but as we get closer to treatments that can work on patients with unmethylated MGMT, this becomes of utmost importance. To recap: MGMT is a repair enzyme that can fix the damage caused by Temozolomide, making the cells resistant to Temozolomide. "Methylation of MGMT" means that the gene that codes for the MGMT repair enzyme is blocked so it cannot make the MGMT enzyme - which gives a better result for Temozolomide. "Unmethylated MGMT" thus means that the gene is not blocked, and it makes the repair enzyme, so Temozolomide has much less chance of helping. The controversy is that most tests do not say you are 100% methylated or unmethylated. It is open to interpretation of where the cutoff between methylated and unmethylated lies. Pathology labs should show the % of methylated cells in addition to the label of unmethylated or methylated, as this cutoff value can change.
