Effects of tumor treating fields (TTFields) on glioblastoma cells are augmented by mitotic checkpoint inhibition. I am a big fan of Optune. It is the most effective approved treatment for gbms, but it is not good enough by itself. We need to find ways to make it work better. There are about 16 clinical trials going on now that involve Optune and ways to make it work better. Any of these trials are worthwhile to try. Experiments like this are needed to identify candidates for the trials.