Brain Tumor Webinars! This next webinar is about a vaccine that looks promising. Bring all of your questions about vaccines and other immunotherapies!
Note that we use Zoom as the meeting room and Zoom has been doing a lot of security updates recently so leave a few extra minutes in case you need to download the latest version of zoom (it might tell you you have to update before joining the webinar). It is simple - just follow the directions - but it may take a few extra minutes and we usually start right on time!
This is the last webinar in our Brain Tumor Awareness Month Webinar series - but we will add more webinars when we find an interesting topic / speaker! Feel free to suggest topics and speakers!
ONC201 in previously irradiated pediatric H3 K27M-mutant glioma or newly diagnosed DIPG. This is one of many abstracts about Onc201 presented at the Annual American Society of Clinical Oncology conference taking place this week. To see the entire list of Onc201 abstracts, go to: https://oncoceutics.com/oncoceutics-to-present-additional-data-at-asco-showing-clinical-benefit-from-onc201-for-cancer-patients/
This abstract reports on a fascinating finding. Onc201 is an experimental oral drug that blocks DRD2. Tumors with the H3K27m mutation, mostly diffuse midline glioma and DIPG, usually have a high expression of DRD2 so should benefit most from this drug. The research shows that the tumors that respond best to Onc201 have a low level of EGFR and conversely, tumors with a high EGFR do not respond as well. Their conclusion is that EGFR and DRD2 perform similiar functions - so if EGFR is high, blocking DRD2 doesn't help much. My conclusion is that we should try to combine Onc201 with a drug or vaccine that blocks EGFR - perhaps we will have a treatment that most high grade brain tumors respond to.
Disclosure: The Musella Foundation gave a venture philanthropy grant to Oncoceutics and will benefit if Onc201 is ever FDA approved.
Musella Foundation Copay Assistance program is running low on funding This program is a life saver. I started it because both of my family members who had glioblastomas also had problems with the cost of their treatments. The program is funded by donations directed to this program and does NOT take anything away from the money we raise for brain tumor research. That is a seperate fund. When making a donation, you can tell us which fund to apply your donation to and if you want to just fund research, 100% of your donation will go to brain tumor research! You can make donations at https://virtualtrials.com/donate
ASCO Brain Tumor Abstracts From The Experts!
ASCO is one of the 2 biggest brain tumor conferences of the year (SNO is the other one), Here we have 2 of the superstars of the brain tumor world giving their thoughts on the most important abstracts from ASCO!
