Al's Comment:

 Val-083 is an experimental chemotherapy that is similar to Temodar but works on a different part of the DNA of the tumor, which the MGMT repair system can not repair.  Theoretically, it should work in unmethylated MGMT patients as well as Temodar does with Methylated MGMT.  This study hints that it is true.  The study is really too small to tell, but does show an effect.

Posted on: 01/29/2020

DelMar Pharmaceuticals Announces Peer-Reviewed Publication of Interim Results of Phase 2 Clinical Trial of VAL-083 As First-Line Treatment in Newly-Diagnosed MGMT-Unmethylated Glioblastoma Multiforme


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