Al's Comment:

 This is a fascinating gene therapy that can be controlled by an oral drug - the gene therapy is injected into the tumor and it inserts a gene that when activated by the oral drug produces IL-12, which is an immune enhancer.  The problem is too much IL-12 causes severe problems so there is a need to be able to control it. They use this oral drug to control it and can turn off the gene therapy if needed simply by stopping the oral drug. 

They announced the first use of it in a DIPG patient.  They used it on over 175 other patients with other cancers, mostly glioblastoma, with relatively good results.   I wish them luck!


Posted on: 07/09/2020

Ziopharm Oncology Doses First DIPG Patient in Phase 1/2 Trial of Controlled IL-12 for the Treatment of Pediatric Brain Tumors


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