Al's Comment:

 These 2 grants are exciting. 

We did a webinar about the Gallium Maltolate project. See https://virtualtrials.org/video2021.cfm?video=202105 This is a new approach to treating brain tumors. They are trying it on Glioblastomas but it may work for most cancer types - not just brain tumors.

To be honest, I never heard of uORFs before this grant application came in. I had to research what it is, and found that they regulate gene expression and thereby can influence how much of a protein is made by the cell.  Dysfunction of the uORFs may be the underlying cause of many cancers, and very little research has been done into the connection between uORFs and cancer. The researcher chose to work on Group 3 Medulloblastomas because it is known that these tumors rely heavily on translational regulation. If this project is successful it may lead to breakthroughs in all cancer types.


Posted on: 06/06/2021

Musella Foundation awards two more brain tumor research grants!

  
Hewlett, NY 6/6/2021 - The Musella Foundation is pleased to announce that we have awarded two more  brain tumor research grants in the total amount of $50,000.  
 
The projects:
 
  • $25,000 grant to Dr. Jennifer Connelly of the Medical College of Wisconsin for the project: "Oral Gallium Maltolate for the Treatment of Relapsed and Refractory Glioblastoma".
     
  • $25,000 grant to Dr. John Prensner of the Dana-Farber Cancer Institute for the project: "Comprehensive interrogation of uORFs as a source of new medulloblastoma cancer genes".
     
The funding for these grants came from our National Walk To End Brain Tumors Fundraisers, as well as donations to our organization, many of which were in memory of a loved one who died from a brain tumor.  Thanks to the volunteers and donors who enabled us to make these grants. Although the first project is directly for Glioblastoma and the second for medulloblastoma, they will both help all brain tumor types if successful.
  
 
About the Musella Foundation 
 
The Musella Foundation For Brain Tumor Research & Information, Inc is a 501(c)3 non- profit organization dedicated to speeding up the search for the cure of brain tumors, as well as helping families deal with the diagnosis of brain cancer, by funding innovative brain tumor research, education, advocacy, emotional and financial support for families that are dealing with brain tumors and organizing the brain tumor community to work together as an army to fight the disease. Our patient navigation program is unlike any other such program – a team of experts evaluate each case, and we track the outcomes so we learn from every patient.
 

 


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