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This study showed moderate activity in pretreated high grade gliomas. May be worth considering regorafenib - especially if combined with something. This drug is approved for other types of cancer but can be used off label for brain - although cost may be an issue. No treatments really "work" well in this scenario, so it is impressive that this drug showed the results it did. Of course it is not good enough - which is why I say it needs to be combined with something.