Al's Comment:

 We need more research into this.  Dr Virgina Stark Vance was the first neuro-oncologist to use Avastin for Glioblastomas.  It was scary using it for the first time because the blood vessels in a glioblastoma are messed up and there is a fear that Avastin might cause bleeding into the brain.  So she used 5mg/kg  which was 1/2 of the standard dose  used for Colon cancer at the time. She had remarkable results.   Then many trials were launched to confirm the activity that she saw.  Most of them used the 10mg/kg dose that was popular for Colon Cancer.  The results showed an increase in response rate and progression free survival but no increase in overall survival. However, Dr Vance continued to use the lower dose, which she feels has better outcomes. This study confirms that. 

Posted on: 02/08/2023

Dose-dependent efficacy of bevacizumab in recurrent glioblastoma


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