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This drives me crazy. About 20% of the patients have a major response and at least 1/3 of the patients are helped somewhat with onc-201 alone. This is for dmg and dipg, where no drug has ever shown a response before. The logical next step is to try the combinations we think will make it work for most patients. There are small trials underway to slowly test a few combinations. However, instead of concentrating on making it work better, they decide to waste years, lots of money, and kill patients with a literal sugar pill placebo controlled trial. Shows a complete lack of understanding of what is needed. Drugs like this should be fda approved so every patient can get easy access and we can learn how best to use it.