Al's Comment:

 We (the Musella Foundation) helped fund this first in kids project.    It was intended to see if it was safe enough to use this treatment on kids - and they found it is. 3 of the 8 patients who received the single CED infusion treatment had at least stable disease for a time. One patient was still alive at the end of the study at 22 months.  These were heavily pre-treated patients who had failed an average of 3.5 lines of therapy before trying this treatment.  Although this group of kids did much better measured from first recurrence to death than the average survival expected, it is hard to tell how much of that is due to this treatment as they had so many other treatments as well.  More research is needed.


Posted on: 03/31/2023

Recombinant polio–rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial

 


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