Note: The comments under each article title are the opinion of our president, Al Musella, DPM, and do not reflect official policy of the Musella Foundation!

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07/17/19 ImmunoCellular Therapeutics Announces Asset Purchase Agreement with Private Biotechnology Company        

 This is great news.   ICT-107 is an off the shelf vaccine for GBM.  The early clinical trials looked very good, but the final clinical trial "failed" and they stopped development of it.  However, there were quite a few responses and long term survivors from that trial.  There were probably some mistakes made in that trial design.  Patients that had certain biomarkers did well enough (adding over a year  to median time to progression compared to those without the biomarker)  get FDA approval but patients without those biomarkers had no benefit. Hopefully this new company will run the correct trial and make this vaccine available.  This is literally a shot in the arm (or leg) with the same side effects profile as the flu shot, and there are a few long term survivors out over 7 years who are not only alive, but in good shape, happy and still working.




07/16/19 GBM Awareness Day This Wednesday July 17th!        

 Please look for the hashtag #GBMDay on social media on Wednesday and retweet it so we can get it trending!




07/16/19 Attend an Optune Open House.        

 From our friends at Novocure!   




07/16/19 Neoadjuvant Anti-PD-1 Immunotherapy Leads to Survival Benefit in Recurrent Glioblastoma        

 This is the second publication which conforms that if you are going to have a surgery, it pays to start taking pembrolizumab before the surgery and continue after, instead of starting after.




07/15/19 Phase II study of Dovitinib in recurrent glioblastoma.        

 Unfortunately this treatment did not work.




07/06/19 Insurance type impacts the economic burden and survival of patients with newly diagnosed glioblastoma.        

 As expected, the better insurance you have the better you will do.  This is very significant when we start talking about Medicare for all.  The most popular "medicare for all" plan really is Medicaid for all. It sounds good with no copayments or deductibles, but when you try to limit costs especially for complex cases like a brain tumor, quality has to suffer.

One fault in the article- it says Medicare patients do not live as long as private insurance payments, but they did not correct for age.  Medicare patients are usually older than private insurance patients, especially at the time of the first surgery.  Older people in general do not do as well as younger people.

 

 




07/01/19 Defeat DIPG Executive Director Jenny Mosier Speaks at FDA Public Hearing Regarding ONC201        

 This is one of the most moving speeches about how devastating pediatric brain tumors are and the need to speed up development of treatments.




06/25/19 Integrating Clinical Research And Care In A Perpetual Trial        

This is the wave of the future. It combines everything needed to speed up the search for the cure: finding the best treatments for each individual patient, helping them to get access, and analyzing the results so we learn from each patient.   Instead of trying to find the right patients for a specific treatment, this turns it around and finds the best treatment for a specific patient.

The Musella Foundation is partnering with xCures and Cancer Commons to run compassionate use programs in a new way where we collect the real world data to help speed up drug approvals and learn best how to use drugs.

Disclaimer: I own stock in xCures, and am a consultant for them.




06/24/19 Musella Foundation awards 9 grants!        

 Our largest grant was a payment of $250,000 towards a $1 Million pledge we made to open the compassionate use program for the experimental drug ONC-201 in the USA, and to track the patients so we learn from every patient's experiences.   We are now saving for the next payment, due at the end of this year, as well as another $2 million to open the program in the rest of the world!

 

 




06/22/19 Bayer’s regorafenib kicks off brain cancer platform trial        

 This is the opening of the GBM AGILE trial, which will allow drugs to be tested much faster and easier for GBM. New drugs can be added and underperforming drugs dropped to home in on the best treatment or combination of treatments quickly!

I wish them luck!

 






06/22/19 New Data Demonstrates Safety Profile of GammaTile Therapy for Various Brain Tumors        

 GammaTile is an fda approved treatment which is an implant that slowly releases radiation to the tumor bed.  See more details from our recent webinar on it at:  https://virtualtrials.com/video2019.cfm?video=201905




06/13/19 Webinar: Personalized Approaches to Treating Cancer Explained in Plain Language        

 This is from our friends at Store My Tumor.Com   They provide services to store and freeze your tumor sample from surgery, as well as help you get access to the services that can use this tissue such as specialized testing and even the creation of custom made vaccines!




06/12/19 Glioblastoma Awareness Day Resolution Passes U.S. Senate with Unanimous Support        

 Great job by the people at the National Brain Tumor Society to get the Glioblastoma Awareness Day passed!




06/11/19 Oncology Expert Keith T. Flaherty, MD Named Chairman of xCures Scientific Advisory Board        

 The virtual trial they are talking about is the next generation of our virtual trial registry.  It takes the giant leap into offering ideas for treatment options.  Our program never suggested anything - just observed what patients did and the outcome.  This new program will evaluate each patient and come up with ideas for treatment options that fit their specific profile.

Disclaimer:  I own stock in this company and am a consultant for it.




06/10/19 Attend an Optune Open House.        

 These meeting are to learn about Optune and meet people who are using it!  One of them can be done online, the rest are real wolrd. Very much worth attending if you have a GBM or know someone who has one!




06/03/19 Phase II Trial Shows Favorable Response for Patients Receiving Combination Therapy With SurVaxM        

 This is very impressive.   93% of GBM patients alive at 1 year compared to 65% historical controls.  This treatment is a simple vaccine injection that does not require brain tumor tissue. It is just a shot in the arm or leg similiar to a flu vaccine, and has minimal to no side effects.  A clinical trial recently opened at the Cleveland Clinic, which will combine a checkpoint inhibitor with the vaccine.




06/01/19 Activism Alert: Big Medicare Problem!        

Please help with this.  We can not let Medicare set a precedent with imposing such severe restrictions.  If they get away with it now, it is only going to get worse for the next treatments in the pipeline – which will probably be much more expensive than Optune.




06/01/19 Correction: Medicare Activism Alert        

 Sorry - the link in the last news blast did not work so I am resending this article!

Please help with this.  We can not let Medicare set a precedent with imposing such severe restrictions.  If they get away with it now, it is only going to get worse for the next treatments in the pipeline – which will probably be much more expensive than Optune.




05/30/19 A Clever New Strategy for Treating Cancer, Thanks to Darwin        

 Fascinating article on a new concept in treating cancer. Doesn't mention brain cancer but the same principle probably applies.

The thing that struck me though is the author danced around the obvious solution. He said there were doctors using the concept on their own patients and suggested that we need randomized controlled to prove it works. He missed the obvious solution - what is needed is that all cancer patients need to be tracked in an always on registry so that these "n of 1" trials are analyzed. If 1,000 doctors each try this on 5 patients and do not share the results, we just wasted 5,000 patients' experiences. If they were tracked in a registry, we would have the answer.

 




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