22 patients with recurrent malignant gliome were treated with "8 drugs in 1 day" chemotherapy protocol. 3 patients achieved partial response, 7 achieved stable disease, while 12 had progressive disease. Median time to tumor progression for all patients was 13 weeks, while median survival time for all patients was 35 weeks. Hematological toxicities were the most common, resulting in treatment refusal in two patients. Other toxicities included gastrointestinal, nephrotoxicity and ototoxicity.
