This section of our web site attempts to explain the latest brain tumor treatments
that are in general use in plain English, with a brief overview of each, then
details on the treatments and where to find them. Unlike the rest of the "Clinical
Trials & Noteworthy Treatments For Brain Tumors" site, this section
is only the authors' OPINIONS of the material.
Use it for general information, to get ideas of what is available out there,
but then discuss it with your own doctors.
If you disagree with anything said, have anything to add, or want to help
write a topic, please let us know.
- Advanced MRI imaging New techniques that allow for better differentiation between tumor growth and pseudo-progression as well as early indication of response (or not) to treatment. You can request that your doctor order "Fractional Tumor Burden" (FTB) maps the next time you need a scan. They should be done at every scan as you compare them to each other and can see earlier signs of response or recurrence. Any MRI scanner can do it but they need to contact Imaging Biometrics to get the software needed to make the maps. (Added 4/3/22)
- New Expanded Access Program for MAPK-Pathway Altered Cancers Look at your pathology report. If it says you have alterations in any of these markers, look into this program: KRAS, NRAS, HRAS, BRAF, MEK, and/or ERK. (Added 12/6/2020)
- NCCN Guidelines This is the new version of the National Comprehensive Cancer Network guidelines for the treatment of brain tumors. This is considered the "standard of care". You have to create a free account to access them! (Added 5/22/23)
- Glioblastoma Bill Of Rights From our friends at "Our Brain Bank" (Added 12/10/2020)
- Long term followup on original Optune clinical trial an astounding 20% survival at 15 years (in a small trial). Added 11/23/2020
- Evolution of radiotherapies for brain tumors - the story of GammaTile Therapy. Added 10/26/2020
- Metastatic Brain Tumors - Michael Schulder, MD Added 7/31/2020
- Highlights From ASCO 2020 (discuss them in our forum!) Added 5/30/2020
- Al Musella's ASCO Highlights Part 1
- Al Musella's ASCO Highlights Part 2
- Patrick Wen's Highlights
- ASCO 2020: Abstract Recommendations From Dr. Roger Stupp for Brain Cancer
- Al Musella's thoughts on what he would do if he had a newly diagnosed gbm. https://virtualtrials.org/newsarticle.cfm?item=6333
- Treatment Options for Glioblastomas AND The Role of Supplements (including Anti-Oxidants) in Cancer Treatment By Ben Williams, Ph.D. (Experimental Psychology) ** Updated Aug 2017 READ THIS FIRST!
- ONC-201 - an oral experimental treatment in clinical trials
- Articles by Stephen Western
- Bevacizumab (Avastin) updated: 04/19/2020
- Cancer and Evolution updated: 04/19/2020
- Currently Recruiting Clinical Trials - Glioblastoma updated: 04/19/2020
- Currently Recruiting Clinical Trials - High Grade Glioma updated: 04/19/2020
- Currently Recruiting Clinical Trials - Low Grade Glioma updated: 01/24/2021
- Dasatinib (Sprycel) updated: 04/19/2020
- DCVax (and other dendritic cell vaccines) updated: 04/19/2020
- Diet updated: 04/19/2020
- Glossary of brain tumor terms updated: 04/19/2020
- Immunotherapy updated: 04/19/2020
- NovoTTF (Electric Field Therapy) updated: 04/19/2020
- PCV chemotherapy updated: 04/19/2020
- Photodynamic Therapy updated: 04/19/2020
- Re-educating the Immune System updated: 04/19/2020
- Repurposed Drugs updated: 04/19/2020
- SNO 2014 Highlights updated: 04/21/2019
- SNO 2016 Clinical Highlights updated: 04/19/2020
- Supplements updated: 04/19/2020
- Targeting Glioma Stem Cells updated: 04/21/2019
- Targeting Tumor Associated Macrophages/Microglia updated: 04/19/2020
- Targeting Tumor Invasion updated: 04/19/2020
- Targeting Tumor Metabolism updated: 04/19/2020
- Temozolomide (Temodar) updated: 04/19/2020
- The Blood-Brain Barrier updated: 04/19/2020
- Toca 511 And Toca FC updated: 04/19/2020
- Trial Results - Anaplastic Glioma updated: 04/19/2020
- Trial Results - Anaplastic Glioma - Recurrent updated: 04/19/2020
- Trial Results - Glioblastoma updated: 04/19/2020
- Trial Results - Glioblastoma - Recurrent updated: 04/21/2019
- Trial Results - Oligodendroglioma And Oligoastrocytoma updated: 04/19/2020
- Virotherapy updated: 04/19/2020
- Gliadel Overview updated: 04/19/2020
Leading Edge Radiosurgery (12/2016) Among the best reported results!
- Three-dimensional Exoscope for Brain Tumor Surgery
- Introduction to Radiosurgery (added 2/24/18)
- Transcript of the FDA meeting for the approval of the Novo TTF 100A device (Optune). (This is a huge file - may take time to open)
- What is CED (Convection Enhanced Delivery)? This is a new form of CED that can be used long term.(added 10/28/2010)
- Article on the possible link between viruses - like CMV - and brain tumors
CPT-11 and Avastin for malignant glioma. - early report on a promising new combinaton therapy!
- Avastin and CPT-11, Etoposide or Carboplatin Amazing early results. This one is a must read. Look at the results in the table for those who used Avastin + CPT-11
- Human Corticotropin-Releasing Factor (hCRF) (Xerecept) in Peritumoral
Brain Edema - a possible replacement for Decadron!
By Lisa U. Carr, MD, PhD
Atypical Teratoid Rhabdod Rumor (AT/RT).
- Neuroblate System - Laser surgery
- Vaccine Therapies for Brain Tumors
- Proton Beam Radiation (this is a .pdf file and requires the free pdf reader)
- Abstracts from ASCO 2007 (Reported by Hong Lan) Old but interesting!
- Email Communication for Patients with a life-threatening
illness - one way of dealing with keeping the family "in the loop"!
- Update to Social Security Disability Rules
- Brain Metastases - an overview (last updated 2/18/18)
- The Anti-angiogenic basis of metronomic chemotherapy. (added 7/29/2004) - Doesn't specifically mention brain tumors, but there are trials of this approach going on now with brain tumors.This paper (which is on the technical side) explains the rationale for this approach.
- Future options of anti-angiogenic cancer therapy
- Boron Neutron Capture Therapy:
- Boron Neutron Capture Therapy (BNCT) of Brain
Tumors. (Note - this is also on the technical side and is a large file.) Added 8/24/2004
- Introduction to the special
edition of the Journal of Neuro-Oncology on Boron Neutron Capture Therapy(BNCT). (Note - this is on the technical side - but points to a lot of information on this treatment.)
- Brain Tumor Guide - Newly diagnosed people should start
here first to get an overview of everything before exploring the rest of
- Brain Tumor Symptoms: Overview | Detailed
- 'Leading Edge' Gamma Knife radiosurgery for primarymalignant brain tumors.- this is a new way of using the gamma knife..
this paper is in a pdf. See instructions above if you have a problem loading the paper.
- Immunotherapy for brain tumors. 2 papers by Dr. Roberta
- Temodar® (Temozolomide) For Brain
- General Information
By Andrew Parker
- Recent papers and abstracts on
- What is a Karnofsky Score?
- High Dose Tamoxifen For Brain Tumors:
By Andrew Parker (Updated 6/8/2004)
- Reprint of Research Paper
By William Couldwell, MD, PhD.
NY Medical College, Valhalla, NY
- Brain Tumor Virtual Trial Abstract
about our study!
- Seizures: What to do if you are having
By Virginia V. Jory, Ph.D.
By Danita Acquafredda And George Hunter
- What Are Clinical Trials
By Terri Armstrong, RN, MS, NP, CS
Neuro-Oncology Nurse Practitioner
Emory University, Atlanta, Georgia
- Childhood Hydrocephalus: Clinical Features,
Treatment, and the Slit-Ventricle Syndrome Explanation of the use of
shunts, by Dr. Arno Fried.
- 50 Questions to help communicate with people
who can't talk. By Jim Kenzig
- Thoughts on Alternative Treatments
Guest editorial by Dr. Robert Fink
Click HERE for a list
of FAQs and articles about brain tumors by Dr. Fink.
Disclaimer: The material provided here is controversial and is only the opinion of the person noted as author of a topic. It is provided for informational purposes only and should not be considered as medical advice or instruction.
Consult your health care professional for advice relating to a medical problem or condition.