Authors'Opinions

This section of our web site attempts to explain the latest brain tumor treatments that are in general use in plain English, with a brief overview of each, then details on the treatments and where to find them. Unlike the rest of the "Clinical Trials & Noteworthy Treatments For Brain Tumors" site, this section is only the authors' OPINIONS of the material. Use it for general information, to get ideas of what is available out there, but then discuss it with your own doctors.

If you disagree with anything said, have anything to add, or want to help write a topic, please let us know.


  1. New Expanded Access Program for MAPK-Pathway Altered Cancers Look at your pathology report. If it says you have alterations in any of these markers, look into this program: KRAS, NRAS, HRAS, BRAF, MEK, and/or ERK. (Added 12/6/2020)

  2. NCCN Guidelines This is the new version of the National Comprehensive Cancer Network guidelines for the treatment of brain tumors. This is considered the "standard of care". (Added 11/23/2020)

  3. Glioblastoma Bill Of Rights From our friends at "Our Brain Bank" (Added 12/10/2020)

  4. Long term followup on original Optune clinical trial an astounding 20% survival at 15 years (in a small trial). Added 11/23/2020

  5. Evolution of radiotherapies for brain tumors - the story of GammaTile Therapy. Added 10/26/2020

  6. Metastatic Brain Tumors - Michael Schulder, MD Added 7/31/2020

  7. Highlights From ASCO 2020 (discuss them in our forum!) Added 5/30/2020

    1. Al Musella's ASCO Highlights Part 1

    2. Al Musella's ASCO Highlights Part 2

    3. Patrick Wen's Highlights

    4. ASCO 2020: Abstract Recommendations From Dr. Roger Stupp for Brain Cancer

  8. Al Musella's thoughts on what he would do if he had a newly diagnosed gbm. https://virtualtrials.org/newsarticle.cfm?item=6333

  9. Treatment Options for Glioblastomas AND The Role of Supplements (including Anti-Oxidants) in Cancer Treatment By Ben Williams, Ph.D. (Experimental Psychology) ** Updated Aug 2017 READ THIS FIRST!

  10. ONC-201 - an oral experimental treatment in clinical trials

  11. Articles by Stephen Western of Astrocytoma Options.com

  12. Bevacizumab (Avastin) updated: 04/19/2020

  13. Cancer and Evolution updated: 04/19/2020

  14. Currently Recruiting Clinical Trials - Glioblastoma updated: 04/19/2020

  15. Currently Recruiting Clinical Trials - High Grade Glioma updated: 04/19/2020

  16. Currently Recruiting Clinical Trials - Low Grade Glioma updated: 01/24/2021

  17. Dasatinib (Sprycel) updated: 04/19/2020

  18. DCVax (and other dendritic cell vaccines) updated: 04/19/2020

  19. Diet updated: 04/19/2020

  20. Glossary of brain tumor terms updated: 04/19/2020

  21. Immunotherapy updated: 04/19/2020

  22. NovoTTF (Electric Field Therapy) updated: 04/19/2020

  23. PCV chemotherapy updated: 04/19/2020

  24. Photodynamic Therapy updated: 04/19/2020

  25. Re-educating the Immune System updated: 04/19/2020

  26. Repurposed Drugs updated: 04/19/2020

  27. SNO 2014 Highlights updated: 04/21/2019

  28. SNO 2016 Clinical Highlights updated: 04/19/2020

  29. Supplements updated: 04/19/2020

  30. Targeting Glioma Stem Cells updated: 04/21/2019

  31. Targeting Tumor Associated Macrophages/Microglia updated: 04/19/2020

  32. Targeting Tumor Invasion updated: 04/19/2020

  33. Targeting Tumor Metabolism updated: 04/19/2020

  34. Temozolomide (Temodar) updated: 04/19/2020

  35. The Blood-Brain Barrier updated: 04/19/2020

  36. Toca 511 And Toca FC updated: 04/19/2020

  37. Trial Results - Anaplastic Glioma updated: 04/19/2020

  38. Trial Results - Anaplastic Glioma - Recurrent updated: 04/19/2020

  39. Trial Results - Glioblastoma updated: 04/19/2020

  40. Trial Results - Glioblastoma - Recurrent updated: 04/21/2019

  41. Trial Results - Oligodendroglioma And Oligoastrocytoma updated: 04/19/2020

  42. Virotherapy updated: 04/19/2020



  43. Gliadel Overview updated: 04/19/2020

  44. Leading Edge Radiosurgery (12/2016) Among the best reported results!

  45. Three-dimensional Exoscope for Brain Tumor Surgery

  46. Introduction to Radiosurgery (added 2/24/18)

  47. Transcript of the FDA meeting for the approval of the Novo TTF 100A device (Optune). (This is a huge file - may take time to open)

  48. What is CED (Convection Enhanced Delivery)? This is a new form of CED that can be used long term.(added 10/28/2010)

  49. Article on the possible link between viruses - like CMV - and brain tumors

  50. Avastin

  51. CPT-11 and Avastin for malignant glioma. - early report on a promising new combinaton therapy!

  52. Avastin and CPT-11, Etoposide or Carboplatin Amazing early results. This one is a must read. Look at the results in the table for thos who used Avastin + CPT-11
  53. Human Corticotropin-Releasing Factor (hCRF) (Xerecept) in Peritumoral Brain Edema - a possible replacement for Decadron!
    By Lisa U. Carr, MD, PhD

  54. Medulloblastomas

  55. Atypical Teratoid Rhabdod Rumor (AT/RT).

  56. Neuroblate System - Laser surgery

  57. Vaccine Therapies for Brain Tumors

  58. Proton Beam Radiation (this is a .pdf file and requires the free pdf reader)

  59. Abstracts from ASCO 2007 (Reported by Hong Lan) Old but interesting!

  60. Email Communication for Patients with a life-threatening illness - one way of dealing with keeping the family "in the loop"!

  61. Update to Social Security Disability Rules

  62. Brain Metastases - an overview (last updated 2/18/18)

  63. The Anti-angiogenic basis of metronomic chemotherapy. (added 7/29/2004) - Doesn't specifically mention brain tumors, but there are trials of this approach going on now with brain tumors.This paper (which is on the technical side) explains the rationale for this approach.

  64. Future options of anti-angiogenic cancer therapy

  65. Boron Neutron Capture Therapy:

  66. Boron Neutron Capture Therapy (BNCT) of Brain Tumors. (Note - this is also on the technical side and is a large file.) Added 8/24/2004

  67. Introduction to the special edition of the Journal of Neuro-Oncology on Boron Neutron Capture Therapy(BNCT). (Note - this is on the technical side - but points to a lot of information on this treatment.)
  68. Brain Tumor Guide - Newly diagnosed people should start here first to get an overview of everything before exploring the rest of this website!

  69. Brain Tumor Symptoms: Overview | Detailed

  70. 'Leading Edge' Gamma Knife radiosurgery for primarymalignant brain tumors.- this is a new way of using the gamma knife.. this paper is in a pdf. See instructions above if you have a problem loading the paper.

  71. Immunotherapy for brain tumors. 2 papers by Dr. Roberta Hayes

  72. Temodar® (Temozolomide) For Brain Tumors:
  73. General Information

  74. Review
    By Andrew Parker

  75. Recent papers and abstracts on Temodar
  76. Medulloblastoma

  77. What is a Karnofsky Score?

  78. High Dose Tamoxifen For Brain Tumors:
  79. Review
    By Andrew Parker (Updated 6/8/2004)

  80. Reprint of Research Paper
    By William Couldwell, MD, PhD.
    Neurosurgeon
    NY Medical College, Valhalla, NY
  81. Brain Tumor Virtual Trial Abstract about our study!

  82. Seizures: What to do if you are having a seizure!

  83. CPT-11
    By Virginia V. Jory, Ph.D.

  84. PCV
    By Danita Acquafredda And George Hunter

  85. BCNU

  86. What Are Clinical Trials
    By Terri Armstrong, RN, MS, NP, CS
    Neuro-Oncology Nurse Practitioner
    Emory University, Atlanta, Georgia


  87. Childhood Hydrocephalus: Clinical Features, Treatment, and the Slit-Ventricle Syndrome Explanation of the use of shunts, by Dr. Arno Fried.

  88. 50 Questions to help communicate with people who can't talk. By Jim Kenzig

  89. Thoughts on Alternative Treatments
    Guest editorial by Dr. Robert Fink
    Click HERE for a list of FAQs and articles about brain tumors by Dr. Fink.

    Disclaimer: The material provided here is controversial and is only the opinion of the person noted as author of a topic. It is provided for informational purposes only and should not be considered as medical advice or instruction.
    Consult your health care professional for advice relating to a medical problem or condition.



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