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AP26113 is a second-generation ALK and ROS1 inhibitor that seems in vitro to also have some activity against the activating epidermal growth factor receptor (EGFR) mutations and T790M. It is in clinical trials for lung cancer. I mention it here because it looks like it may work for brain mets from lung cancer. They report: 4 out of 5 central nervous system deposits responding, and we are also getting duration of response data.
Go to: www.medscape.com/viewarticle/807208 for the full text. Unfortunately you may have to register to get in to view it.