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I thought that Avastin crossed the blood brain barrier but this experiment, in mice, shows that opening up the blood brain barrier using a relatively simple application of focused ultrasound leads to vastly improved outcomes and much higher concentration of Avastin in the brain. There is a trial in humans now of administering Avastin via intra-arterial infusion directly into the tumor. We do not have the results yet, but this experiment gives hope that the principle of increasing the dosage to the tumor may work in people!