Sponsored by
This project is funded, in part, by the Musella Foundation!
It shows that that the vaccine can be enhanced significantly by using other immune modulating drugs. The full text of the article is not available for free, only the abstract is free. The full text shows how strong the effect is when using each treatment separately, then in all combinations. It is a major improvement.
This project also shows, I think for the first time, that the immune suppression caused by PD-L1 is created by tumor-infiltrating myeloid cells and not directly by the tumor cells, which is what I always assumed. The huge significance of this is that doing a biopsy of a tumor and testing for PD-L1 on the tumor cells shouldn't make any difference to how the treatment would work.
I would love to see this being done in humans.