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This article looks at the failure of the Nivolumab trial and tries to show why it failed and how we can overcome those failures. This trial used Nivolumab as a monotherapy at the time of first recurrence and it failed to show an improvement in overall survival. The authors say that it may work better in combination with some other treatments that boost the immune system, such as radiation, vaccines or other immunotherpaies. It also may work better with newly diagnosed instead of recurrent patients.