Al's Comment:

 This is a pretty technical article but basically it says that  you need to target both pathways (NOTCH and PI3K)  at the same time to have a major effect.  There are a few drugs approved for PI3K  inhibition and  a few experimental NOTCH inhibitors in clinical trials.  These have to be tried in combination for GBM.

 

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Posted on: 01/26/2019

The Oncogene Addiction Switch from NOTCH to PI3K Requires Simultaneous Targeting of NOTCH and PI3K Pathway Inhibition in Glioblastoma.

 

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