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Val-083 is an experimental chemotherapy drug that is similar to Temodar but works in a slightly different way so that it is not affected by the MGMT repair enzyme, which means it should theoretically work on a Glioblastoma patient with unmethylated MGMT as well as Temodar works on a methylated MGMT glioblastoma. This shows early results which show a hint that it does work this way.
Phase 2 study of Val-083 with radiation therapy for newly diagnosed