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Lessons Learned in Using Laser Interstitial Thermal Therapy (LITT) for Treatment of Brain Tumors: A Case Series of 238 Patients From A Single Institution LITT is a a minimally invasive procedure using laser energy delivered through a catheter, under MRI guidance to destroy tumor or radiation necrosis. It can sometimes be used when an open surgery is too dangerous and is much easier for the patient than a traditional surgery. This article shows how important experience is when using this relatively new technique. The first 100 patients they used it on had a much higher (15.5% vs 4.4%) chance of permanent motor deficits than the subsequent group of 138 patients. Some of the difference might also be explained by advances in the equipment and software.