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Each part of this combination did well in early trials, and the idea of combining them is that the oncolytic virus will create an inflammatory reaction around the tumor which would make the Car-T cells work better. For other types of cancers, Car-t cells provided cures in a high % of patients, but so far hasn't been able to repeat that level of success in brain tumors. This combination is an attempt at the home run - bringing that success to brain tumors.
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