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This is just a single case report - so do not get too excited about the combination. What IS exciting is the process. I love the way this team of doctors approached this case and think it should be used on all cases of brain tumors. They do a deep analysis of the tumor and fgure out the pathways that drive the tumor. In the past, you would pick the pathway you think is the most important, and target it. What is different here is they try to hit all of the important pathways at the same time with a new combination of drugs that was never tried before. They use intra-patient dose escalation to figure out the right dosage of the drugs.