Al's Comment:

 This is an amazing invention.  They modified a common bacteria so that it preferentially infects glioblastoma cells. A lot of work needs to be done before this can be used as a treatment but it is a completely new approach of delivering treatments to the tumor cells. They claim it is a lot safer than viruses - the bacteria are very sensitive to many antibiotics - although they do say it is possible for them to mutate to antibiotic resistance so they need to build in a separate kill switch before using on people. It is also much larger than viruses -  it can theoretically allow multiple mechanisms of killing tumor cells built into each virus.  I will keep an eye on this and let you know of future progress!


Posted on: 12/12/2023

Generating Shigella that internalize into glioblastoma cells

 


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