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Sonodynamic therapy is using noninvasive focused ultrasound to kill tumor cells that take up a special dye, In theory - this can kill the tumor cells without hurting the normal cells. It is still experimental and early, but it is one of the most promising new approaches. There are three different forms of it being tested now - hopefully all of them will work and we do not know which is best right now. Focused ultrasound is also being used to treat brain tumors in other ways such as by opening the blood brain barrier allowing other treatment in, and by physically heating the tumor to ablate it.
SonALAsense reported on the first group of pediatric DIPG cases treated. This was dose escalation, so most did not get the full therapeutic dose. They had impressive results. The best part is that there is no incision, no pain, no systemic side effects and relatively easy to undergo. It can be repeated as needed. If it works like I think it will,
The Musella Foundation is one of the sponsors of this research!