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This is brilliant work. A huge problem we have is that when a patient is diagnosed with having MGMT Unmethylated Glioblastoma, it is much less likely that Temozolomide will help, and they have been shown to have a much shorter survival time. These researcher figured out a way to convert MGMT unmethylated tumors into MGMT methylated tumors, using a viral delivery of CRISPR. It is still only pre-clinical but a new approach that should help a lot!