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This model incorporated mutational and copy number aberration data to simulate personalized GBM tumor response and generate efficacy predictions for radiation and TMZ. The model worked well to predict radiation therapy response but was not as robust for TMZ. Interestingly, among the model's predictions of the 3 best combo therapies for each patient (n=98), only 2.4% (7 of 294) of 2-drug combo recommendations included TMZ. This study further emphasizes the need for personalized precision treatment in GBM.