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A new study from MD Anderson Cancer Center reports promising outcomes using GammaTile (cesium-131 collagen tile) brachytherapy for brain metastases recurring after prior stereotactic radiosurgery (SRS). Among 31 patients with brain metastases, most commonly from breast (37%) or non-small cell lung cancer (26%), all underwent surgical resection with GammaTile placement. Gross total resection was achieved in 84% of cases. At a median follow-up of 11.8 months, local failure occurred in 13% overall and just 6.4% when complete resection was achieved. One-year overall survival was 65.8%, with low toxicity—only 8% developed grade 2+ radiation necrosis. Subtotal resection, tumor volume, multiple prior radiation courses, and dural contact were associated with higher failure risk. These results support GammaTile as a potential effective, low-toxicity salvage option for recurrent brain metastases.