Al's Comment:

 Leptomeningeal spread is a serious complication.  Left untreated, average survival is only 2 months.  The article talks about a few treatments but there is an interesting clinical trial going on specifically for patients with leptomeningeal  spread: Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma  It is too early to tell how good this works, but the alternatives do not seem that good either. Car-T cells have worked miracles in other cancers. This is a new type of Car-T cell treatment that hopefully will work for brain tumors!  They picked the absolute worst situation to test it in - so if it does work we should know quickly. Unlike most immunotherapies, Car-T cells have the possibility (at least in other cancers) of working quickly. 
Disclaimer: The company running the trial, Mustang Bio, is a sponsor of the Musella Foundation.  

Posted on: 01/05/2021

Leptomeningeal Spread in Glioblastoma: Diagnostic and Therapeutic Challenges


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