Al's Comment:

 This trial is for Glioblastomas, Ependymoma or Medulloblastomas that have leptomeningeal spread.  Leptomeningeal spread is when the tumor cells spread via the cerebral spinal fluid to the lining of the brain and spinal cord.  It is a very bad sign. Doing a google search for it shows only completely hopelessness.  Most trials exclude patients with leptomeningeal spread because the outlook is so grim and nothing has really been shown to provide lasting benefit.  This trial is targeting these people with the worst of the worst tumors.  It is worth a try as there really aren't many alternatives. [Disclaimer: Mustang Bio is a sponsor of the Musella Foundation]

Posted on: 05/18/2021

Mustang Bio and City of Hope Announce First Patient Dosed in Phase 1 Clinical Trial of MB-101 (IL13Rα2-specific CAR T cells) to Treat Leptomeningeal Brain Tumors


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