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This is a confusing study. It goes against what we thought was true about using temozolomide. This study was in anaplastic astrocytomas, and showed that there is very little benefit in using temozolomide at the same time as radiation but there is a large benefit using it after radiation. However, that only applies to certain subgroups. In some subgroups of patients temozolomide did not help at all. We will be having a webinar next month on a new test that should simplify this and better predict which patients would benefit from Temozolomide or other treatments.