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This is exciting. The checkpoint inhibitors were miraculous for other types of cancer but did not seem to help brain tumors because brain tumors are immunologically "cold". This paper says that Optune can help turn the tumor into a "hot" tumor, which makes it more amenable to treatment with checkpoint inhibitors. Early research seems to show it works. More research is needed to figure out the optimal timing and dosages but this is the type of thing we can do from within our patient navigation program and registry! So if you are thinking of trying the combination, join our program first so we can track it! https://virtualtrials.org/xcelsior.cfm
[Disclaimer: Novocure is a sponsor of the Musella Foundation]