Al's Comment:

 This article talks about the combination of Onc-201 and paxalisib for DIPG.  It says that Onc-201 works by itself for DIPG but usually the tumor develops resistance to it through the P13K pathway.   Paxalisib targets this P13K pathway so it makes sense to try the combination. They treated 2 patients under compassionate use and both had dramatic reductions in tumor volume, complete resolution of symptoms and extended survival.  So they started a trial https://clinicaltrials.gov/ct2/show/NCT05009992 for the combination to use in DIPG and DMG.  I will be watching this trial closely.


Posted on: 06/13/2022

POSITIVE DATA FOR PAXALISIB IN TWO CHILDHOOD BRAIN CANCERS PRESENTED AT 20TH ISPNO ANNUAL MEETING

 


Click HERE to return to brain tumor news headlines.


Our privacy / cookie policy has changed.
Click
HERE to read it!