This is another form of Sonodynamic Therapy - as I mentioned recently, this is one of the most promising new therapies for brain tumors. It is noninvasive, and can be repeated if needed. This trial is https://clinicaltrials.gov/ct2/show/NCT05362409 which is "Study to Evaluate 5-ALA Combined With CV01 Delivery of Ultrasound in Recurrent High Grade Glioma". Eligible patients have recurrent grade 3 or 4 brain tumors including Oligodendroglioma, anaplastic astrocytoma and Glioblastoma! this trial excludes DIPG but the other sonodynamic therapy trial I recently mentioned does allow DIPG.