Al's Comment:

  It appears that they did not take into account the reason why some people continued taking Temozolomide past 12 months - could it be they were in better shape so they continued? Or the opposite - Temozolomide stopped working so they stopped taking it.  This question can only be answered by a randomized blinded trial - I doubt that will ever happen because Temozolomide is generic and such a trial is expensive - and I doubt anyone would volunteer for such a trial.

Posted on: 07/30/2022

Continuing maintenance temozolomide therapy beyond 12 cycles confers no clinical benefit over discontinuation at 12 cycles in patients with IDH1/2-wildtype glioblastoma


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