Al's Comment:

 This article talks about a new way to get drugs into the brain.  CED is convection enhanced delivery, and it has been used for a long time as a one shot deal.  Now this system can be used over time, in this case 4 treatments once a week for 4 weeks.  Topotecan is a drug that works great against brain tumors in the test tube, but doesn't cross the blood brain barrier so it doesn't work when given IV.  These researchers tried it with this new form of extended CED and early results look promising. All 5 patients had significant reduction in tumor size. That is great news because the FDA has said it would approve treatments quickly if they had a high response rate.  Topotecan is already approved, and this CED system is not a permanent implant - it is easily removed.  Once it is approved we can try all sorts of drug cocktails personalized to the biopsy.

Posted on: 12/01/2022

Convection-enhanced delivery of Topotecan active in glioblastoma


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