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The recent findings on the addition of Lomustine to the standard treatment of Temozolomide and Optune for Glioblastoma patients are particularly intriguing. The study showed that when the MGMT status is methylated, the effect of Temozolomide combined with Lomustine and Optune is additive, resulting in a cumulative effect that is equal to the sum of the individual effects. However, for patients with unmethylated MGMT, the effect is found to be synergistic, which suggests that the combination of these drugs results in a cumulative effect that is greater than the sum of the individual effects. These findings have important implications for the development of more effective treatment strategies for Glioblastoma patients and should be explored further.