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This article talks about using 5ALA to find tumor cells outside of the area that shows up as tumor on MRI. They conclude that it would be useful to analyze these cells for targeted therapies but missed the obvious use: sonodynamic therapy. If 5ALA can find the tumor cells outside of the main tumor which doesn't show up on MRI, then using focused ultrasound to kill the cells that take up 5ALA may be effective in preventing recurrence.