Al's Comment:

I'm a strong advocate for focused ultrasound, a versatile tool for treating brain tumors. The article introduces an innovative application for this technology. The issue at hand is that the immunotherapy drug intended for use cannot penetrate the tumor in sufficient concentrations to be effective. To address this, researchers have developed a pro-drug—a modified version of the drug—that can infiltrate the tumor. This pro-drug is then converted into the active drug specifically within the tumor area using focused ultrasound. This approach has the potential to facilitate the delivery of various drugs to the tumor. The selected drug has shown promising results in mouse models, and hopefully, clinical trials in humans will commence soon.

Posted on: 08/26/2023

Prodrug-loaded semiconducting polymer hydrogels for deep-tissue sono-immunotherapy of orthotopic glioblastoma


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