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This is really interesting research on improving the durability of treatment response from Tumor Treating Fields (TTF). This preclinical study found two key factors related to TTFields treatment resistance: a receptor called EP3 and a protein called ZNF488. These proteins work together to help cancer stem cells survive and grow, making them resistant to TTFields. When researchers blocked these proteins, the cancer cells became sensitive to TTFields again, and their ability to grow and form tumors was reduced. Blocking EP3 also helped stop resistance before it started. This discovery suggests that targeting EP3 and ZNF488 could help overcome resistance to TTFields, not only in GBM but potentially in other cancers as well.