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This is interesting new research from UCLA. They found that a plant-derived compound called forskolin can cross the blood-brain barrier and can be used synergistically with radiation. Recent research has shown that radiation may temporarily make glioma stem cells more flexible, so researchers theorized that adding forskolin at the right moment could exploit this flexibility by pushing the cells towards a less harmful (i.e. nondividing) neuron-like or microglia-like state. When they tested the dual combination in mice, the approach extended median survival and, in some cases, led to long-term tumor control.