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Previously, craniectomy (removing a small portion of the skull) had been shown to increase penetration of tumor-treating fields (TTF) into the brain. However, the factors that modulate this effect were still unknown. This recent article shows that the biomaterials used to fill the opening, the gross tumor volume relative to the opening size, and the amount of edema around the tumor are important factors. These insights may help optimize the application of TTFields for better treatment results in the future.