Vanessa's Comment:

This is interesting preclinical work showing that adding pemigatinib, a FGFR1-3 inhibitor, to tumor-treating fields (TTFields) reduced glioma stem cell (GSC) growth, survival, and clonogenicity in lab models. Adding radiation to the TTFields + pemigatinib combo also appeared to delay DNA damage repair, further enhancing the overall effect in some GSC lines. While this work is still early-stage, it could offer a new angle to overcoming TTFields therapy resistance. 


Posted on: 06/09/2025

FGFR inhibition as a new therapeutic strategy to sensitize glioblastoma stem cells to tumor treating fields

 


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