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A large 37-year analysis of over 20,000 patients from the Traumatic Brain Injury Model Systems National Database found that a history of traumatic brain injury (TBI) is associated with a 1.75-fold higher risk of death from brain cancer compared to the general population. The risk was especially pronounced in certain subgroups, including patients with gunshot-related TBIs (over 14-fold higher risk) and those with “mild but complicated” injuries. Researchers believe chronic post-injury inflammation may contribute, and while these findings do not prove causation, they suggest TBI may have long-term oncologic as well as neurologic consequences that deserve further study.