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This doubled survival for recurrent glioblastoma and is easily available. Worth considering.
We are planning to introduce version 2.0 of the Promising Pathway Act sometime next week. This open house is for patient advocates to hear about the act and to network with other groups. If you are in the area, we need people to show up to let them know we support this bill!
Excellent paper on sonodynamic therapy - the history, mechonism of action, current trials and future prospects. The authors discuss all of the available devices - not just their own. I beleive this therapy is going to be a major breakthrough in the treatment of brain tumors. It is very elegant, non-invasive, early indications are that it is safe and well toerated, and it can be repeated as often as needed.
This study showed that it is relatively safe and feasible to do repeated convection enhanced delivery of drugs to the brain - particularly the pons. The drug they used, MTX110 is a nanoparticle formulation of Panobinostat. This was a dose escalation study - so most patients did not get an effective dose - but it still showed an improvement in survival compared to what we know about the outcome of this disease.
There is a problem with slow adoption of new treatments. I was taught to never be the first one to prescribe a new treatment, or the last one to prescribe a bad treatment. That is ingrained in most doctors, but it doesn't apply when dealing with a deadly disease. You need to take the risk / benefit ratio into account. For something like gamma tiles, which have shown very impressive results with glioblastomas as well as metastatic tumors, we do not have the time to wait. Patients who need brain tumor surgery need to ask their doctors if it GammaTile is appropriate for thier case. Check the list of doctors who are trained in the use of GammaTiles at https://gtmedtech.com/gammatile-centers/ If your doctor is not on the list and says they are not appropriate, get a quick second opinion from one who is on the list. It is worth checking.
I love this combination. We usually recommend the CUSP0v3 protocol as an option to patients and usually suggest adding Optune to it. This study confirms that the combination makes sense. We do not have enough patients using this combination yet to tell how well it works but will be watching it! So if you are thinking of trying it, participate in our patient navigation program / registry so we can track it! Go to https://virtualtrials.org/xcelsior.cfm to get started!
We are planning to introduce version 2.0 of the Promising Pathway Act sometime next week. This open house is for patient advocates to hear about the act and to network with other groups. If you are in the area, we need people to show up to let them know we support this bill! Note: A previous version of the invitation had the wrong date. It is Feb 27, 2024.
Sonodynamic therapy is one of my favorite new treatments. It is very elegant in how it works to noninvasively target cancer cells while minimizing damage to the normal cells. Early results look very good. Keep in mind the first few patients presented had a low dose and few treatments. It will get better and better as they learn how best to use it!
We have the ability to speed up the process of making this available - it is a matter of money - but in this case a lot of money. So as the speaker mentions in the talk, if you have any interest and ability to make either a large ($1-5 million) donation or investment in the company, contact me!
Very small trial but interesting results.
Vorasidenib did very good in trials for IDH mutant gliomas and have now applied for FDA approval. We should hear the decision by August!
Sonodynamic therapy is an exciting, non-invasive experimental treatment for brain tumors. I think it will be shown to be a breakthrough and will significantly impact this disease. This webinar is at a different date and time than usual - we wanted to get it to you as soon as possible!
From our good friends at Our Brain Bank.
Interesting new approach to treating glioblastoma. Very early results look good! Will keep an eye on this.
Sonodynamic therapy is an exciting, non-invasive experimental treatment for brain tumors. I think it will be shown to be a breakthrough and will significantly impact this disease. This webinar is at a different date and time than usual - we wanted to get it to you as soon as possible!
This looks promising. Still too early to tell, but early results look good.
This is a new generation of EGFR inhibitor that gets through the blood brain barrier and targets multiple mutations in EGFR. Worth looking into if your pathology report showed alterations in EGFR!
We increased our income guidelines - see the website for details but for a family of 4, we now allow up to $156,000 in income! We also take into account if you will make less money due to the tumor.
